MatHIFU
MatHIFU is a toolbox for the control of the Sonalleve system in a Matlab environment. The Sonalleve is an MR-guided High Intensity Focused Ultrasound for therapy. MatHIFU allows the execution of user-defined treatment protocols such as thermal ablation, hyperthermia or drug delivery. MatHIFU allows the execution of treatment protocols where the user can specify the commands to be executed for the ultrasound exposure. MatHIFU can handle any number of protocols that can be executed according to the user needs.
Initial development of this project was done by my Research Engineer Tony Sinclair and later the undergraduate student Benjamin Zaporzan developed the current version.
Initial development of this project was done by my Research Engineer Tony Sinclair and later the undergraduate student Benjamin Zaporzan developed the current version.
Distribution
MatHIFU is being hosted at github as a private repository and it is aimed to be freely available to researchers under coordination of Philips Healthcare. Please contact me for further inquirees
Journal article and citation
An open access journal article was accepted in the Journal of Therapeutic Ultrasound. The article showcase several applications where MatHIFU is used. You can access the paper with this link. The article can be cited as: Journal of Therapeutic Ultrasound 2013, 1:7 doi:10.1186/2050-5736-1-7
Main functionality
The most important commands that are available include:
- Position of transducer (x, y, z + 2 rotation angles) with feedback
- Trajectory of dynamic focusing with control of power, time step and duty cycle
- Real-time update of commands
- Low-level commands to specify custom phase-corrections
- Polling of status
Example of use
The following code is a full listing of an example to execute a simple sonication protocol and update it dynamically. The protocol creates an exposure with a power of 30W and 20s of length by default. Ten seconds after initiated the exposure, the power and location of the focal point are modified. The exposure is stopped 5s later. The final duration is 15s.
Application example
In this example for showcasing, MatMRI and MatHIFU were combined to produce a heating pattern that recreated the letters in the word "HIFU". Each of the ten lines in the pattern was produced by electronically steering the focal point along 18-mm-long lines over 8 s. LR denotes the left-right direction, and HF denotes the head-foot direction. For more details, please consult the journal article.
Published studies using MatHIFU
- Pichardo, S,, Mougenot, C., Engler, S., Waspe, A. C.,, Drake, J. On Demand Reprogramming of MR Sequence Parameters Using MatMRI. ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore- Abstract 3593.
- On-Demand Dynamic Updating of the Temporal Resolution of Interleaved PRFS and T2 Temperature Mapping Methods for MR-HIFU. Engler, S., Mougenot, C., Keupp, J., Weiss, S, Heijman, E. Pichardo, S.. ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore- Abstract 2110
- Pichardo, S., Köhler, M., Lee, J. and Hynnyen, K., 2014. In vivo optimisation study for multi-baseline MR-based thermometry in the context of hyperthermia using MR-guided high intensity focused ultrasound for head and neck applications. International Journal of Hyperthermia, 30(8), pp.579-592.
- Price, K.D., Sin, V.W., Mougenot, C., Pichardo, S., Looi, T., Waspe, A.C. and Drake, J.M., 2016. Design and validation of an MR-conditional robot for transcranial focused ultrasound surgery in infants. Medical Physics, 43(9), pp.4983-4995.
- Mougenot, C., Pichardo, S., Engler, S., Waspe, A., Colas, E.C. and Drake, J.M., 2016. A rapid magnetic resonance acoustic radiation force imaging sequence for ultrasonic refocusing. Physics in Medicine and Biology, 61(15), p.5724.
- Bing, C., Nofiele, J., Staruch, R., Ladouceur-Wodzak, M., Chatzinoff, Y., Ranjan, A. and Chopra, R., 2015. Localised hyperthermia in rodent models using an MRI-compatible high-intensity focused ultrasound system.International Journal of Hyperthermia, 31(8), pp.813-822.